Olive leaf‐derived PPAR agonist complex induces collagen IV synthesis in human skin models. Topical application of Aronia melanocarpa extract rich in chlorogenic acid and rutin reduces UVB-induced skin damage via attenuating collagen disruption in mice. Her Y, Lee TK, Kim JD, Kim B, Sim H, Lee JC, et al. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Sci Study Res Chem Chem Eng Biotechnol Food Industry. Development and validation of a dissolution test for ursodeoxycholic acid and taurine from combined formulation. Acceleration of wound healing activity with syringic acid in streptozotocin induced diabetic rats. Factors influencing collagen biosynthesis. Structure and metabolism of collagens in various pathologies. Plants in vitro propagation with its applications in food, pharmaceuticals and cosmetic industries current scenario and future approaches. Hasnain A, Naqvi SAH, Ayesha SI, Khalid F, Ellahi M, Iqbal S, et al. Perindopril arginine and amlodipine besylate for hypertension: a safety evaluation. Genophenotypic factors and pharmacogenomics in adverse drug reactions. ![]() DOI: 10.1007/s41991-9Ĭacabelos R, Naidoo V, Corzo L, Cacabelos N, Carril JC. Adverse drug reactions in older adults: a narrative review of the literature. Zazzara MB, Palmer K, Vetrano DL, Carfì A, Onder G. Recombinant collagens allow to obtain proteins with new programmed features, making it possible to synthesize proteins with predetermined properties for medical use. Fundamentally different possibilities for the influence of plant organisms on collagens are opened with the use of genetically modified plants. Such a variety of methods for collagens metabolism regulation creates a wide range of possibilities for developing new preparations based on extracts or pure plant compounds able to correct connective tissue collagen structure and metabolic disorders with minimal adverse effects. In particular, this is characteristic of triterpenes and phytoestrogens. Besides TGF-beta1 others cytokines can also be involved in the processes of collagen metabolism regulation by compounds of plant origin. ![]() In addition, a fairly common are effects on collagen synthesis by changing organism's pools of free amino acids (as the starting compounds for this protein synthesis) and by regulation of hydroxylases (performing collagen post-translational modifications and crosslinking). Among them, the most common are the direct influence of the substance on the processes of collagen genes expression and indirect influence via TGF-beta1- pathway. Most of the studied compounds realize their effects simultaneously by several mechanisms. Biologically active compounds of plant origin can both stimulate and inhibit the biosynthesis of various types collagens, accelerate or slower down their catabolism, regulate the activity of enzymes involved in the collagen's metabolism. The review summarizes information on possibilities of plant preparations use for collagen structure and metabolism disturbances correction. Plant preparations, collagen structure, collagen metabolism, disturbances correction, recombinant collagens Abstract Igor Sikorsky Kyiv Polytechnic Institute, Ukraine Open International University of Human Development "Ukraine", Ukraine SI "Institute of Pharmacology & Toxicology of the National Academy of Medical Sciences of Ukraine", Ukraine
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |